App-V: Office 2010 Word "Problem sending command to the program."
If you get this error when trying to double click Word documents do the following, this was taken from the App-V Forums, can't find the original author:
In the console goto File Type Associations.
Find the .doc association and right click it, then click Properties.
Click "&Open" and then click edit on the right.
Change the parameters to: /n /dde
Check Use DDE.
Change DDE Message to: [FileOpen("%1")]
Change DDE Application to: winword
Change DDE Topic to: system
This should apply the same changes to .docx but check it to make sure.